Тромбоз, гемостаз и реология. — 2016.

ПЕРИОПЕРАЦИОННЫЕ КОАГУЛОПАТИИ В ОНКОХИРУРГИИ. КОНЦЕНТРАТ ПРОТРОМБИНОВОГО КОМПЛЕКСА

И. В. Нехаев, А. О. Приходченко, П. В. Вяткин, А. В. Сытов, С. В. Ломидзе

ФГБУ «Российский онкологический научный центр имени Н. Н. Блохина» Министерства здравоохранения Российской Федерации, Москва, Россия

Настоящее проспективное исследование основано на изучении клинико-лабораторных показателей у 36 пациентов (17 женщин и 19 мужчин), оперированных по поводу злокачественных новообразований различной локализации. У всех пациентов в раннем послеоперационном периоде отмечалось насыщенное геморрагическое отделяемое по дренажу/ам на фоне адекватной классической гемостатической терапии. Всем больным вводили концентрат протромбинового комплекса, который оказался эффективен и клинически и лабораторно, и имел хороший профиль безопасности. Совокупность данных коагулограммы, тромбоэластометрии и уровень тромбоцитов оптимальны для мониторинга периоперационных коагулопатий.

Ключевые слова: периоперационные коагулопатии — концентрат протромбинового комплекса — коагулограмма — тромбоэластометрия — онкохирургия.

PERIOPERATIVE COAGULOPATHIES IN ONCOSURGERY. PROTHROMBIN COMPLEX CONCENTRATE

I. V. Nekhaev, A. O. Prikhodchenko, P. V. Vyatkin, A. V. Sytov, S. V. Lomidze

N. N. Blokhin Russian Cancer Research Center, Moscow, Russia

This prospective study is based on analysis of clinical and laboratory parameters in 36 patients (17 women and 19 men) operated because of malignant neoplasms of various localization. In early postoperative period in all patients we revealed saturated hemorrhagic secretion through drainage/s under adequate classic hemostatic therapy. All patients received prothrombin complex concentrate which was clinically and laboratory effective and had good safety profile. Coagulogram parameters, thromboelastometry data and platelets level are optimal for monitoring of perioperative coagulopathy.

Key words: perioperative coagulopathies — prothrombin complex concentrate —coagulogramma — thromboelastometry — oncosurgery.

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Тромбоз, гемостаз и реология. — 2016. — №1(65). — С. 39-50.

Оригинальные исследования

ПЕРИОПЕРАЦИОННЫЕ КОАГУЛОПАТИИ В ОНКОХИРУРГИИ. КОНЦЕНТРАТ ПРОТРОМБИНОВОГО КОМПЛЕКСА

PERIOPERATIVE COAGULOPATHIES IN ONCOSURGERY. PROTHROMBIN COMPLEX CONCENTRATE